[Efficacy and safety of inactivated novel coronavirus vaccine inoculation in patients with chronic hepatitis B].

Objective: To explore the safety of inactivated novel coronavirus vaccine inoculation and the fluctuating neutralizing antibody in patients with chronic hepatitis B (CHB). Methods: Retrospective and prospective epidemiological research methods were employed. 153 CHB patients who visited the Department of Infectious Diseases at the First Hospital of Shanxi Medical University from September 2021 to February 2022 were selected as the research subjects. Information on vaccination-related adverse reactions was collected. Colloidal gold immunochromatography was used to identify neutralizing antibodies in the body after 3-6 months of vaccination. Statistical analysis was performed using the χ2-test or Fisher's exact test. Results: The positive rates of neutralizing antibodies after inactivated novel coronavirus vaccine inoculation in 153 patients with CHB were 45.50%, 44.70%, 40.00% and 16.20%, respectively, at 3, 4, 5, and 6 months. The neutralizing antibody concentrations were 10.00 (2.95, 30.01) U/ml, 6.08 (3.41, 24.50) U/ml, 5.90 (3.93, 14.68) U/ml, and 1.25 (0.92, 3.75) U/ml, respectively. The difference was not statistically significant (P>0.05) when the neutralizing antibody positivity rates in hepatitis B virus (HBV) DNA-negative and positive patients and HBeAg-negative and positive patients at different time points were compared. The overall incidence of adverse reactions following vaccination was 18.30%. Pain at the site of inoculation and fatigue were the main presentations, and no serious adverse reactions occurred. Conclusion: CHB patients, when inoculated with an inactivated novel coronavirus vaccine, can produce neutralizing antibodies, which can stay at certain levels for 3, 4, and 5 months. However, the neutralizing antibody level gradually decreases over time, and the decrease is remarkable at 6 months. So, it is recommended to boost vaccinations at an appropriate time. Additionally, the results of the study suggest that HBV replication status has little effect on the production of neutralizing antibodies in CHB patients with relatively stable liver function, which means the inactivated novel coronavirus vaccine has a good safety profile.

A Study on Functional Satisfaction with Smart Health Care Air Purification Product in the Post-epidemic Era

In the context of the COVID-19, respiratory diseases have become the focus of social attention, and the elderly, as a susceptible population, is more significantly affected by the epidemic. In order to fully protect the respiratory system of the elderly and enhance their satisfaction with the function of smart products, this study proposes a design method for smart health care product based on the cognitive behavior of elderly users. Firstly, the user demand gap is explored and determined by using the A-Kano model;secondly, a functional model is created based on the FAST functional theory. After converting the user demand into function, and then the TRIZ theory is applied to choose to use 40 invention principles and 39 general engineering parameters to analyze the problem and get conflict domain solutions, so as to filter out the most ideal solution and innovate its function;Finally, by the design and practice of the smart health care air purification product, its purification range, monitoring data and wearing method will be effectively optimized, and the feasibility of the design solution will be verified by the user interaction satisfaction questionnaire. The study provides new ideas for the design of smart health care products and the solutions of contradictory problems, which would also be a theoretical guidance for relevant designer and researchers. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

Experience Report on the Use of Breakout Rooms in a Large Online Course

In this paper, we present our experience with the use of breakout rooms in a second year undergraduate Software Design course at a large North American institution. Following the switch to remote instruction during the coronavirus pandemic, we revamped our in-person Software Design course to be delivered as a flipped online course, making extensive use of in-lecture exercises completed during breakout rooms. We report on the structure and logistics of this lecture design (for a large class of 300+ students). To gain insights into the impact of the use of breakout rooms on student experience, we conducted weekly student surveys asking for feedback on the lectures and specifically on the use of breakout rooms. Although many students had positive feelings regarding the use of breakout rooms, a significant percentage of students (an average of 47% of the survey responses each week) expressed negative feelings toward them. In an end-of-term survey, we specifically asked students about what they felt worked best for breakout rooms in terms of group size and pre-assigned versus randomized groups, and if there were any other areas that they felt needed improvement. Some of the patterns we observed were that most students liked smaller groups (2-5 people), preferred staying in the same group throughout the semester, and enjoyed the use of breakout rooms as long as others in their room were active participants. We share the details of these survey results as well as the tips and lessons that we learned through this experience. © 2022 ACM.

Will the Supporting Policies Help the Recovery of SMEs during the Pandemic of COVID-19? - Evidence from Chinese Listed Companies

Employing the method of fuzzy Regression Discontinuity Design (Fuzzy-RDD) with 12220 valid sample data from 2,444 enterprises and with data duration covering from February to June 2020, this paper studied the effectiveness of supporting policies for small and medium-sized enterprises (SMEs) during the COVID-19 in China. The study found that the policies which were implemented are beneficial for wholesale enterprises recovery. However, they are not beneficial for manufacturing, transportation and information transmission industries. Suggestions were put forward to the government about how to improve the support policies' effectiveness for SMEs.

Artificial Seawall by Blasting Squeezing Silt and amelioration treatments in Saline-alkali Soil with Toilet Revolution without sewers

Artificial seawall by silt squeezing with blasting dike, a small price for a good seawall than with mechanical dredging, and is effective in preventing this kind of accident from tsunami and typhoon disaster. This paper briefly discusses the pollution situation of poultry and mankind waste in China. For the first time gives the techniques for harmless (China patent ZL 201220109642.1, no flush heathy toilet.) and utilization of waste in China are presented and analysed for benefit utilization. Sanitary toilet without sewers -2019 world break-through technologies (no flush heathy toilet) driven reinvent the toilet challenge, RTTC. Authors also show the technique for harass and utilization of wastes in China. The authors suggest that all the mankind and animal waste, after harmless processing, should be used in a way of useful things as feed, fertilizer, etc. to benefit human society, prevent disease (covid-19, sars) propagation and reduce greenhouse gases. It is also can be used on ship, aircraft, coach and out space etc. (China patent ZL 201220109642.1 is one of several ways of human and livestock faeces harmless treatment, ultraviolet disinfection, ozone fumigation), its weight less than 15kg, volume less than 0.12m3. © Published under licence by IOP Publishing Ltd.